Ping Failing from collector to device and back?

1 hour ago, Mike Moniz said:

have collectors located on the same network segment as the devices being monitored so not hitting firewalls

This is the recommended architecture.

1 hour ago, mnagel said:

most organizations these days are moving to internal compartmentalization, which means firewalls of some sort

If your firewalls are blocking legitimate business traffic, they need to not do that.