Does cloud watch API calls bound to Data Sources or Data points?

You could modify the AppliesTo of the cloud datasources to exclude certain VMs.

For example (in Azure, but similar for other cloud providers): MicrosoftAzure_VMBackupStatus has the following AppliesTo:

hasCategory("Azure/VirtualMachine") && system.azure.hasBackupProtectedItemResource == "true"

You could add something that looks for a property and if that property is present, the VM is excluded from applying to that DS:

hasCategory("Azure/VirtualMachine") && system.azure.hasBackupProtectedItemResource == "true" && noCloudMetrics

Then you’d just add a property called “noCloudMetrics” to any VMs you want that DS not to apply to. It doesn’t matter what the value is. This expression just looks for that property to exist.