Alert for datasource instance datapoints based on Instance Description. Currently we cannot create an alert for datasource instance based on Instance description.

As a kinda messy workaround, you can clone the DataSource you want to use so you have two version:

1. 1. Informational version covering all instances with no alert thresholds which you can use for graphs and performance data.
2. 2. Alerting version that uses Auto Discovery filtering to ONLY contains instances based on the naming you want to alert on and has global threshold values.

This does mean that you are performing some checks multiple times but would be more automatic than manually setting thresholds per interface. Still like the idea of having an instance option in Alert Rules though.